Molecular and Microbial Ecology - Research Projects

Sequence of Yersinia pestis biovar antiqua

Yersinia pestis, the causative agent of plague, possesses a highly conserved genome among different isolates.  This pathogen is believed to have recently emerged as a highly uniform clone from the enteric pathogen, Yersinia pseudotuberculosis.  The complete genome sequence of the orientalis biovar, CO-92 and the mediaevalis biovar, KIM10, confirm the high conservation of sequence identity between different strains of Y. pestis.  We are currently sequencing two antiqua biovars of Y. pestis, Antiqua, isolated from the Republic of Congo and Nepal516, isolated from Nepal. The aim of the current study was to identify polymorphic sequences that could be used to differentiate strains of Y. pestis and to study the evolutionary relatedness of strains that have been isolated from different parts of the world.

Link for sequences
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